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Itrakonazol, ketokonazol i u manjoj meri flukonazol i vorikonazol su snažni inhibitori izoenzima CYP3A4 citohroma P450 i mogu povećati koncentraciju benzodiazepina u plazmi.Fenobarbital uzet istovremeno može dovesti do aditivnog efekta na CNS. Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzi

These indicators include restlessness and experience irritable. In case you have previously been having it for a while and want to stop, your medical professional will advise which you cut down your dose slowly and gradually in order to avoid the potential risk of these results.four. Clinical particulars four.one Therapeutic indications To the shor

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